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ZIP Code. Primary Specialty. Primary Work Setting. Create new account. Forgot Password If you forgot your password, please click here to reset it. Abstract Number:. Sitagliptin Improved Beta-Cell Function in Patients with Type 2 Diabetes T2DM : A Model-Based Analysis [beta]-cell dysfunction occurs [beta]-cell dysfunction occurs early in T2DM and is characterized by abnormalities such as depressed [beta]-cell sensitivity to glucose with respect to insulin release.
Incretins have been shown to enhance [beta]-cell function in patients with T2DM and in animal models of diabetes.
Since sitagliptin SIT; a DPP-4 inhibitor increases active incretin levels, [beta]-cell function was assessed using frequently sampled 9-points meal tolerance tests MTT in sub-studies from 3 Phase III trials 2 monotherapy studies and an add-on to metformin study using a model-based analysis. For the MTT, blood was collected at0, 10, 20, 30, 60, 90,and min relative to start of the meal.
Insulin sensitivity was assessed with a validated composite index ISI. The disposition indices, which assess insulin secretion in the context of changes in insulin sensitivity, were also assessed.
Disposition indices were also broadly improved with SIT treatment relative to placebo. Despite enhanced [beta]-cell sensitivity to glucose, the very low rate of hypoglycemia observed in clinical trials with SIT indicated that the increase in [beta]-cell function remained glucose-dependent. In summary, SIT improved [beta]-cell function in both fasting and postprandial states.Thanks for helping us catch any problems with articles on DeepDyve. We'll do our best to fix them.
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After 12 weeks, the IGI was Fasting glucose at baseline was 6. Sitagliptin was well tolerated. Journal of Internal Medicine — Wiley. Enjoy affordable access to over 18 million articles from more than 15, peer-reviewed journals.
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The investigators propose a double-blind, randomized controlled pilot study comparing the effect of sitagliptin a novel anti-diabetic drug with beta-cell protective potential versus placebo, on the preservation of beta-cell function over one year in patients with T2DM on metformin, the first-line agent for the treatment of T2DM ie.
This study may demonstrate an important beta-cell protective capacity of sitagliptin. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms x. COVID is an emerging, rapidly evolving situation. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Results First Posted : December 29, Last Update Posted : January 2, Study Description. Detailed Description:. Medications currently used in the treatment of T2DM have not been shown to modify the progressive decline in beta-cell function that occurs over time.
Recent evidence, however, suggests that a new class of anti-diabetic medications, called dipeptidyl peptidase-IV DPP-IV inhibitors, may be able to protect beta cells and hence alter the natural history of T2DM. We thus wish to study the effect of sitagliptin a DPP-IV inhibitor on the preservation of beta-cell function in patients with T2DM randomized to either i sitagliptin and metformin or ii placebo and metformin.
FDA Resources. Arms and Interventions. Outcome Measures. A higher value indicates better beta-cell function. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Women should not be planning pregnancy for the duration of the study. Reliable contraception includes: birth control pill, intra-uterine device, abstinence, tubal ligation, partner vasectomy, or condoms with spermicide.Skip to main content.
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Create new account. Forgot Password If you forgot your password, please click here to reset it.Gliptin Symposium(Sitagliptin): Drs Mohan, Shashank J, Krishna Sheshadri, A K Singh..
Abstract Number:. Influence of Measures of Beta Cell Function on Efficacy of Sitagliptin in Patients with Type 2 Diabetes Beta cell dysfunction is a hal Beta cell dysfunction is a hallmark of type 2 diabetes, with a substantial loss of function already evident at diagnosis. This model included terms for treatment, trial, baseline BCF subgroup and the treatment-by-subgroup interaction with covariates for baseline efficacy values and prior antihyperglycemic treatment status.
Editor who approved publication: Prof. Muthuswamy Balasubramanyam. Patients and Methods: This was a cross-sectional and observational study in comparison to the control group. Indices for beta-cell function, peripheral insulin sensitivity, and insulin resistance were calculated with homeostasis model assessment 2 HOMA2 calculator and compared. Serum GLP-1 concentrations were analyzed, and regression analysis was conducted to find the correlations between GLP-1 and beta-cell function and insulin resistance.
Results: Newly diagnosed patients with T2D witnessed a significant reduction in beta-cell function, serum GLP-1 concentrations at the time of diagnosis.
Serum GLP-1 concentrations were increased significantly to those levels in the control group and correlated with peripheral insulin sensitivity and insulin resistance in patients whose beta-cell functions improved.
Conclusion: Sitagliptin improved beta-cell function, insulin resistance and blood glucose in newly diagnosed patients with T2D. Meanwhile, Sitagliptin ameliorated serum GLP-1 concentrations, which contributed to the enhancement of beta-cell. Keywords: Sitagliptin, serum GLP-1 concentrations, beta-cell function, insulin resistance, newly diagnosed patients with type 2 diabetes mellitus.
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Received 23 March Published 19 June Volume Pages — Review by Single anonymous peer review. Editor who approved publication: Prof. Muthuswamy Balasubramanyam. Patients and Methods: This was a cross-sectional and observational study in comparison to the control group. Indices for beta-cell function, peripheral insulin sensitivity, and insulin resistance were calculated with homeostasis model assessment 2 HOMA2 calculator and compared.
Serum GLP-1 concentrations were analyzed, and regression analysis was conducted to find the correlations between GLP-1 and beta-cell function and insulin resistance. Results: Newly diagnosed patients with T2D witnessed a significant reduction in beta-cell function, serum GLP-1 concentrations at the time of diagnosis.
Serum GLP-1 concentrations were increased significantly to those levels in the control group and correlated with peripheral insulin sensitivity and insulin resistance in patients whose beta-cell functions improved. Conclusion: Sitagliptin improved beta-cell function, insulin resistance and blood glucose in newly diagnosed patients with T2D. Meanwhile, Sitagliptin ameliorated serum GLP-1 concentrations, which contributed to the enhancement of beta-cell.
Keywords: Sitagliptin, serum GLP-1 concentrations, beta-cell function, insulin resistance, newly diagnosed patients with type 2 diabetes mellitus. Diabetes which is a chronic metabolic disorder has recently sharply increased on a global scale. Nowadays, anti-DPP4 antihyperglycemic agents have been widely used for patients with T2D under guidelines of diabetes associations and proved to be effective in the enhancement of beta-cell function via ameliorating serum incretin hormone concentrations two major incretins, GLP-1 and glucose-dependent insulinotropic polypeptide [GIP] - an anti-beta-cell apoptosis agent.
The former was markedly known as Exedin-4 and the latter was well-known with Sitagliptin. Whilst anti-DPP4 agents have many effects on antihyperglycemic conditions, there have been little researches on the Asian population to investigate the role of these drugs on beta-cell function, peripheral insulin sensitivity, insulin resistance and serum GLP-1 concentrations in comparison to healthy subjects but results were controversial.
Regarding Vietnam, albeit Sitagliptin has been recruited as a clinical treatment therapy for patients with T2D for several years, there has been no research on the effect of Sitagliptin to beta-cell function as well as insulin resistance.My husband and I have already talked about going back to Iceland and we expect to book with Nordic Visitor again.
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Beta-Cell Function and Sitagliptin Trial (BEST) (BEST)
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